Peyton Manning returns to Indianapolis for the first time since his trade to Denver, where he'll face Andrew Luck and Colts owner Jim Irsay, who's thrown some less-than-flattering remarks the elder Manning's way.
Tom Brady showed up when it counted when the Patriots stunned the New Orleans Saints in Week 6's dying moments, but they'll look to open up a bigger lead against the New York Jets on Sunday.
And, despite sputtered starts, the Baltimore Ravens and Pittsburgh Steelers will try to re-energize one of the NFL's greatest recent rivalries in Pennsylvania, at Heinz Field.